Springer

  • This expanded edition represents the state of the art and captures many changes in our understanding of status epilepticus over the past decade. Varied characteristics and treatment approaches, the growing use of continuous EEG monitoring, and insights into the underlying biology and pathophysiology of convulsive and nonconvulsive SE are covered in depth. Authored by leading neurologists, epileptologists, and clinical neurophysiologists from around the world, this volume prepares the clinician to confront these multifaceted, sometimes subtle, and occasionally life-threatening conditions.

  • As health care costs soar there is increasing interest in examining what society and, particularly, patients receive in return for these expenditures. Optimizing Health brings together the best thinking from both sides of the Atlantic to explore these issues. It employs disciplinary perspectives from economics, ethics, philosophy, psychology, clinical practice, and epidemiology to explore various ways that value for patients have and can be determined. It concludes with a discussion of changes required in practice, research, and health care systems to maximize the outcomes received from the provision of medical care services from the patient's perspective.
    The first section of the book provides theoretical perspectives from economics and systems thinking that help us to focus on how one might determine the value of medical care for patients. The next section considers the ethical and philosophical dilemmas that face developed countries in distributing medical care. How is justice served and evidence-based medicine employed to increase the value of medical care for patients?
    The section on psychology deals with measuring outcomes from the patient's perspective and involving patients in medical decision making. Measuring quality of life and gaining valid quality of life information when patients cannot respond for themselves are important topics covered by these chapters. Other chapters consider ways that patients can become more involved in medical decision making with the expectation that this will increase the value of medical care for patients.
    A major section of the book about clinical practice discusses problems that can reduce the value to patients of medical care. These include overdiagnosis, aggressive treatments that do not result in better patient outcomes, findings that earlier diagnosis does not always result in better outcomes, and the extent of medical error in treatment.
    The final sections deal with cost-effectiveness analyses and applications of clinical epidemiology. The chapters include a number of original investigations and applications of new methodologies. All-in-all, the volume is must reading for practitioners, policy makers, and researchers who want to find in one place the state-of-the-art thinking and future directions of valuing medical care from the patient's perspective.
    Ronald Andersen
    Wasserman Professor Emeritus of the Departments of Health Services and Sociology at the University of California School of Public Health in Los Angeles

  • This volume brings together educational effectiveness research and international large-scale assessments, demonstrating how the two fields can be applied to inspire and improve each other, and providing readers direct links to instruments that cover a broad range of topics and have been shown to work in more than 70 countries. The book's initial chapters introduce and summarize recent discussions and developments in the conceptualization, implementation, and evaluation of international large-scale context assessments and provide an outlook on possible future developments. Subsequently, three thematic sections - "Student Background", "Outcomes of Education Beyond Achievement", and "Learning in Schools" - each present a series of chapters that provide the conceptual background for a wide range of important topics in education research, policy, and practice. Each chapter defines a conceptual framework that relates recent findings in the educational effectiveness research literature to current issues in education policy and practice. These frameworks were used to develop interesting and relevant indicators that may be used for meaningful reporting from international assessments, other cross-cultural research, or national studies. Using the example of one particular survey (the Programme for International Student Assessment (PISA 2015)), this volume links all theoretical considerations to fully developed questionnaire material that was field trailed and evaluated in questionnaires for students and their parents as well as teachers and principals in their schools. The primary purposes of this book are to inform readers about how education effectiveness research and international large-scale assessments are already interacting to inform research and policymaking; to identify areas where a closer collaboration of both fields or input from other areas could further improve this work; to provide sound theoretical frameworks for future work in both fields; and finally to relate these theoretical debates to currently available and evaluated material for future context assessments. 

  • This volume describes the basics for short- and long-term treatment of Psychogenic Non-Epileptic Seizures (PNES) in children. The text acknowledges that the disorder, though rare and highly morbid, is treatable when it is not misdiagnosed. Given the limited diagnostic and clinical training offered to clinicians, this book aims to equip professionals with the tools needed to improve the poor quality of life of youth with PNES.
    The text begins by introducing the main features of the disorder and the problems involved in diagnosing PNES in children. It then describes techniques to overcome these problems in order to make a reliable and valid diagnosis of PNES, as well as provide feedback on the diagnosis and treatment plan. The last section describes the indications for cognitive behavior therapy for youth with PNES and suggested treatment paradigms. Incorporation of do's and don'ts and their relevant clinical examples in all sections of the proposed guide provide the reader with skills and techniques. The book also includes an appendix with resources for parents, children, and school nurses and teachers, relaxation techniques for the child and parents, templates of letters for the child's school about the condition and behavior management plan, templates of supporting letters from epileptologists and primary care physicians, CBT treatment paradigm, and information on individual supervision, workshops and webinars.
    Written by the few experts in this area, Pediatric Psychogenic Non-Epileptic Seizures is the ultimate guide for psychiatrists, psychologists, nurses, primary care physicians, neurologists, epileptologists, social workers, nurses, school counselors, and all medical professionals working with children experiencing seizures.

  • ?Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells.  The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur.  Errors in DNA replication can lead to genome instability and cancer.  The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process.  A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. 
    /> The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity.  This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA.   It is the cellular protein machinery that enables replication initiation to be activated and regulated.  We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

  • Digital Pathology: Historical Perspectives, Current Concepts & Future Applications provides the authoritative text in the digital pathology domain by combining the established expertise of leaders in this diverse arena with practical applications of this transformative platform while harnessing a content rich, interactive format. In detailing a cohesive narrative from a broad, global perspective the lessons learned from the past, the obstacles to digital pathology adoption that have been overcome and the challenges that remain for full realization of the potential that computational analysis affords, this text provides readers with the latest in where the field is heading as it seeks to unlock the potential of digital pathology by leveraging cutting edge technologies and innovative tools.Digital Pathology: Historical Perspectives, Current Concepts & Future Applications will be of great value to Pathologists including Translational Researchers and Informaticists, Pathology Trainees including Residents and Informatics Fellows, Healthcare CMIOs and CIOs, Bioimaging Engineers and Computer Vision Scientists, as well as Laboratory Information Technologists.

  • This text provides a high level, comprehensive but concise review of adult surgical critical care.  It can be used to review complex topics of critical illness in surgical patients, as a reference tool, or as preparation for a board examination.  It is focused on the surgical patient including high yield facts, evidence-based guidelines, and critical care principles.  To remain succinct, it concentrates on surgically relevant care.  Further, the text is written with an expectation that reader already possesses a basic understanding of critical care pathophysiology and clinical practices such as those acquired during residency. Organized by organ system, each section contains several chapters addressing relevant disorders, monitoring and treatment modalities, and outcomes.      
    Principles of Adult Surgical Critical Care will be of use to intensivists caring for surgical patients regardless of parent training domain. Additionally, this work is intended to be used by surgical critical care fellowship trainees as well as other advanced practice providers such as nurse practitioners and physician assistants who provide care in ICUs and emergency departments alike.  

  • This book represents the first comprehensive, gold standard reader on research integrity in the biomedical sciences. Now more than ever, the responsible conduct of research (RCR) has become critically important as new technologies affect research practices in both positive and negative ways. Since learning to do science and practicing it brings researchers into contact with a vast array of ethical issues, it is critical to know the standards and how they are evolving. Indeed, research integrity requires scientists at all levels to operate ethically in a system that supports ethical practice.   This unique, foundational text covers all the relevant areas -- subject protection, research misconduct and conflict of interest as well as newly quantified concerns about research bias and non-reproducibility, as well as other unique issues. Developed by renowned experts, this compelling title discusses the full range of practices and policies that should support research that is honestly produced and disseminated. It also specifically incorporates topics noted by the National Institutes of Health as essential and required for training in RCR. Getting to Good - Research Integrity in the Biomedical Sciences is a major contribution to the literature on bioethics and will serve as an invaluable resource for all researchers, students, administrators and professionals interested in research ethics and integrity.

  • This volume is about understanding the relationship between deviance and selected correlates of deviance in one generation and deviance and its selected correlates in the next generation. By examining the significance of these constructs in the parental generation as part of the explanation for the same constructs in the child's generation, we contribute to an und- standing of the phenomena. This contribution, however, is quite limited in the sense that we are examining in essence bivariate relationships-the association between first-generation and second-generation phenomena- while ignoring all of the other influences on the second-generation p- nomena that do not stem from or account for the intergenerational relationship. Nevertheless, the study of intergenerational parallelism of deviance and its correlates justifiably has excited attention and resulted in a vo- minous literature greater than might have been expected for any parti- lar bivariate relationships because of the mystique surrounding ideas-cycle of violence, reproduction of culture, to name but a few-that are evoked by consideration of the association between such phenomena in one generation and the same phenomena in a successive generation.

  • Careful evaluation of the placenta can often give much insight into disorders of pregnancy in the mother and fetus. The techniques of gross placental examination are not difficult, but a systematic approach is necessary to be complete. Color Atlas of Gross Placental Pathology, Second Edition is designed to aid in the careful and thorough gross examination of the placenta by providing an illustrated manual of examination that includes normal variations, abnormal findings, as well as unusual pathology.
    "...this atlas contains a wealth of important information for pathologists examining the placenta and provides superb illustrations. This atlas is highly recommended for all those engaged in pathologic examination of the placenta."
    Archives of Pathology & Laboratory Medicine
    "The quality of any atlas depends on clear and appropriate illustrations and concise text in a format that allows for rapid identification of specific entities. This atlas has both. The quality of the illustrations is top rate."
    American Journal of Surgical Pathology

  • Treatment of Benign Prostatic Hyperplasia: Modern Techniques is an up-to-date review of modern techniques used to treat benign prostatic hyperplasia. It provides a comprehensive review of both office and operating room based techniques. Both electrosurgical and laser based techniques are covered. These include high powered 532 nm laser photoselective laser vaporization of the prostate (PVP), holmium laser enucleation/ablation of the prostate (HoLEP/HoLAP), and Bipolar Electrovaporization of the Prostate (Bipolar EVP/Bipolar TURP). In addition, a comprehensive review of office based techniques and future therapies currently being developed is presented. Each of these techniques are presented in a balanced fashion with a focus on modern literature. Treatment of Benign Prostatic Hyperplasia: Modern Techniques will be of great value to Urologists, Urology Residents, Iternists, and Family Practitioners. ?

  • The topography of the brainstem is complex, and even experienced neurologists find it challenging to localize brainstem lesions and diagnose brainstem disorders. This richly illustrated book provides a comprehensive review of brainstem disorders and presents the clinical knowledge necessary for diagnosis. The opening sections document the brainstem neuroanatomy and discuss current diagnostic methods. The entire spectrum of clinical findings in brainstem disorders is then described, and topodiagnostic aspects of the neurological findings are explained in detail. The descriptions of brain stem disorders are consistently structured and are supported by many MR images and short case reports. In addition to primary brainstem lesions, such as vascular brainstem syndromes, other disorders are considered that do not exclusively show brainstem symptoms or signs, e.g., multiple sclerosis. This book will serve as an invaluable reference work for neurologists in clinical practice or further education.

  • Written for comprehensive ophthalmologists and vitreoretinal surgeons, this book discusses state-of-the-art medical and surgical management of cystoid macular edema (CME) and explains the current understanding of the pathophysiology of the condition and methods of diagnosis. The management approach is clearly detailed for each potential presentation, including CME occurring in association with uveitis, diabetes mellitus, vitreoretinal interface changes, retinal vascular occlusions, and lens-induced pathology. The guidance takes full account of the continued expansion in medical treatment options due to the development of new drugs and the increased availability of minimally invasive surgical procedures. Additionally, since therapeutic approaches to CME depend on a clear understanding of pathophysiologic mechanisms and the structural changes in the vitreous and neurosensory retina revealed by imaging studies, these aspects are carefully considered as well.

  • This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.

  • This comprehensive third edition provides robust support to clinicians providing perioperative care for patients. Patients with a range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address their needs, whether pre- or post-surgery. This book offers evidence and experience-based information, advice, and guidelines on all aspects of perioperative medicine. Care around surgeries in many major clinical areas are included, including cardiology, pulmonology, gastroenterology, rheumatology, endocrinology, and so on. This new edition has been updated throughout with the latest literature, more visual content (tables and algorithms), and eleven new chapters on topics such as: chronic pain, congestive heart failure, hormone therapy and transgender patients, and postoperative hypoxemia. This new edition focuses on high value care in order to improve outcomes, including minimizing complications and readmissions. It also provides streamlined key points for caring for patients with medical diagnoses that may be especially complicated around surgery. This resource is invaluable for practicing physicians (including medical consultants, surgeons, and anesthesiologists) and other professionals who aim to optimize care of surgical patients.

  • The 2012 International Conference on Applied Biotechnology (ICAB 2012) was held in Tianjin, China on October 18-19, 2012. It provides not only a platform for domestic and foreign researchers to exchange their ideas and experiences with the application-oriented research of biotechnology, but also an opportunity to promote the development and prosperity of the biotechnology industry. The proceedings of ICAB 2012 mainly focus on the world's latest scientific research and techniques in applied biotechnology, including Industrial Microbial Technology, Food Biotechnology, Pharmaceutical Biotechnology, Environmental Biotechnology, Marine Biotechnology, Agricultural Biotechnology, Biological Materials and Bio-energy Technology, Advances in Biotechnology, and Future Trends in Biotechnology. These proceedings are intended for scientists and researchers engaging in applied biotechnology. Professor Pingkai Ouyang is the President of the Nanjing University of Technology, China. Professor Tongcun Zhang is the Director of the Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education at the College of Bioengineering, Tianjin University of Science and Technology, China. Dr. Samuel Kaplan is a Professor at the Department of Microbiology & Molecular Genetics at the University of Texas at Houston Medical School, Houston, Texas, USA. Dr. Bill Skarnes is a Professor at Wellcome Trust Sanger Institute, United Kingdom.

  • This book provides basic information on the botanical diversity in the Czech Republic and relates the patterns in flora and vegetation to environmental factors, biogeographical history and human impact. Focusing on vascular plants, bryophytes and lichens, it summarizes the data on taxonomic diversity and provides details of relict, endemic, rare, alien and other biogeographically important species. Main vegetation types are characterized in terms of their structure, distribution, ecology and dynamics, emphasizing the long-term vegetation changes since the late Pleistocene, historical impact of humans on vegetation and current changes in vegetation including the impact of alien species. Special attention is paid to the conservation of threatened plant species and their habitats and ecological restoration. An account of the history of botanical research in this country is also provided. The book is illustrated with numerous maps, graphs and photographs of plant species and communities. The book is an essential reference for any biogeographer, botanist and plant ecologist who is working in Central Europe or is searching for both general and more specific information on this part of the world.

  • This volume explores intergenerational practices and their impact on social sustainability, with an emphasis on developing programmatic efforts to address profound social challenges such as underperforming educational and work-related systems, failing support systems for dependent or vulnerable populations, and community renewal and regeneration efforts. To this end, the core argument is to present issues related to age, aging, and generations, not only as problems, but as catalysts to facilitate improved quality of life for all generations.For societies to be sustainable, all generations must coexist at any given time and across time (non-contemporary generations). Hence, the ultimate vision presented here is one of intergenerational sustainability as both a conceptual tool and as a call for action. Intergenerational pathways are introduced as strategies for improving health and well-being across the lifespan, strengthening families, improving under-performing educational and work-related systems, and helping to build more cohesive, caring communities. Reviewing some of the historical factors and developments influencing intergenerational studies, as well as presenting regional case studies and comparative research, this book presents successful models that may be applied to everyday multigenerational practices in institutions such as education, family life, housing, healthcare, employment, and community development.   The result is an accessible resource for students, academics, policymakers, community leaders, and citizens concerned with creating opportunities amidst challenging demographic and social changes.

empty